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Massive apoptosis of colonocytes induced by butyrate deprivation overloads resident macrophages and promotes the recruitment of circulating monocytes

(U) Printer Platens and Ribbons

Cell Mol Life Sci 69:33813394 Dringen R, Hamprecht B, Broer S (1998) The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary cultures

GPx1 deficiency may also (partially) protect liver hepatocytes against acetaminophen-mediated toxicity by mechanisms that decrease protein nitration and cell death, whereas GPx1 overexpressing mice are more sensitive to acetaminophen-mediated hepatotoxicity, in part due to an exhaustion of GSH [175]

FDA-approved with 15-17% body weight reduction demonstrated in Phase 3 STEP trials

Adjustments are made based on how the patient responds
