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[DOI] [PubMed] [Google Scholar] 34.Kinoshita Y, Ishihara S, Kadowaki Y, et al

(c) compliance to drug therapy, (d) causes of worsening like use of nonsteroidal anti-inflammatory drugs, ongoing myocardial ischemia, pulmonary emboli, systemic infection, or chronic right ventricular pacing (Alcohol abuse or binge drinking)

FEBS Lett 2013

This may be related to the findings that high levels of ROS can mitigate metastasis and tumorigenesis, for example in cancer cells detaching from the extracellular matrix [42,43]

These findings suggest a serotonergic contribution to the pathogenesis of nonmotor symptoms, such as depression and anxiety, during the premotor stages of PD