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Nrf2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia-induced brain endothelial cell apoptosis

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of Catanzaro Magna Graecia, Catanzaro, Italy Objective : This pilot randomized controlled trial aimed to assess the efficacy of combination of oxygen-ozone therapy (O2O3) and proprioceptive neuromuscular facilitation (PNF) program vs