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Role of bile acid-regulated nuclear receptor FXR and G protein-coupled receptor TGR5 in regulation of cardiorenal syndrome (Cardiovascular disease and chronic kidney disease)

[2] Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer (PubMed, 2024) Content: A non-randomized in vitro and in vivo study showing how inhibiting carnitine transport can make lung cancer cells more sensitive to immunotherapy

How L-carnitine fulfills these potential functions is not completely understood, and a better comprehension can be realized through further mechanistic studies

A total of 48 female Mus musculus C57BL/6 (FMO3 +/+) strain WT and 40 female Mus musculus C57BL/6-Fmo3 em1Smoc (KO) mice (Cat