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A study indicated that the activation of both ERK and p38MAPK pathways is crucial in the process of Nrf2 nuclear translocation and HO-1 gene activation triggered by DAS (169)

Immortalized cell lines, like ciPTEC, represent a steady and reproducible cell source for in vitro models, but are derived from one single donor and show significant changes in cell function and morphology compared to primary cells (Astashkina et al

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Additionally, exogenous BDNF has a protective effect against ethanol-induced damage in primary culture neurons from rat hippocampi (66)

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