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doi: 10.1016/S0140-6736(21)00569-9

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Karagac MS, Ceylan H (2023) Neuroprotective potential of tannic acid against neurotoxic outputs of monosodium glutamate in rat cerebral cortex

This distinction helps explain why it progressed into formal obesity trials, whereas the raw fragment itself did not

This has led to interest in NAC for conditions like systemic lupus erythematosus (SLE), where a small RCT found that NAC (2.4-4.8 g/day) improved disease activity scores and reduced anti-dsDNA antibody levels (Lai et al., Lupus, 2012) [42]