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While apoptosis involves caspase activation, chromatin fragmentation and the phagocytosis of cell bodies, which minimizes inflammation, necrosis is defined by cell swelling and lysis with release of intracellular components, which elicits an inflammatory response [9]

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For individuals with metabolic risk factors, insulin resistance, chronic inflammation, or a family history of obesity-associated cancers, GLP-1 therapy in the context of a comprehensive, physician-guided longevity programme may represent a valuable adjunct to conventional preventive medicine strategies