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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the key players contributing to oxidative stress generated intrinsically from normal cellular metabolism, and extrinsically, from environmental factors such as toxins, UV radiation, or cigarette smoke (Forman and Zhang, 2021)

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References 1 AchacheH.RevelA

10.26355/eurrev_201803_14468 112 LibbyP.AikawaM

The detrimental effects of Cl result from interference in the uptake or metabolism of other essential ions, such as nitrate ion (NO 3 ) (Zhao et al., 2020)