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For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under ~35 drops/min) had no distress

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Furthermore, MKR mice were insulin-resistant, had high serum and tissue lipid levels, and developed diabetes at a young age (114)
