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Chemical Properties Source: NCBI PubChem public domain data 2D structure diagram from NCBI PubChem

Tesamorelin acts via the GH axis: it is GH itself that primarily reduces insulin sensitivity, whilst IGF-1 also elevated by tesamorelin has insulin-like properties that may partially counterbalance this effect

doi:10.3177/jnsv.56.109 [PubMed][CrossRef] 31

In addition, the timing, dosing sequence, and pharmacokinetic matching between metabolic modulators and conventional therapeutics remain difficult to optimize

Statistical analysis All statistical analysis was completed using either R or GraphPad Prism (v.10.6.1)