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UPR is a highly conserved pathway that monitors endoplasmic reticulum (ER) proteostasis, allowing cells to manage ER stress (Moncan et al., 2021)

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The synthesis process includes multiple steps: Lysine residues are methylated to form -N-trimethyl-lysine (TML), which requires vitamin C, vitamin B6, niacin and iron as cofactors

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Journal of Neurological Sciences 155.2 (1998): 192-195

While it is not a direct weight-loss supplement, studies suggest it may contribute to modest reductions in body weight and fat mass when combined with a healthy diet and regular exercise