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The null allelic variant arose from a recombination event during evolution between two highly homologous regions flanking this locus, resulting in deletion of a 20 kb segment of the gene 42, 43

Hassan et al., The micronutrient Mg 2+ also has been proposed as a treatment for NIHL, not only for its function as a potential cochlear vasodilator but for other pharmacological properties, which include modulation of NMDA glutamate receptors and the regulation of calcium influx into hair cells, preventing or reducing apoptosis (Cevette et al., 2006

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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Nkanga CI, Krause RWM

APN is anchored to the apical membranes of the kidney proximal tubules by a hydrophobic stretch of amino acids at the N-terminus