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Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study

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Duplancic B, Stambolija V, Holjevac J, Zemba M, Balenovic I, Drmic D, et al

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Antiepileptic Medications including: valproic acid (Depakene, Stavzor), carbamazepine (Carbatrol, Epitol, Tegretol, and others), and phenytoin (Dilantin) increase the catabolism rate of vitamin B6 vitamers, resulting in low plasma PLP concentrations and high homocysteine levels

For infants aged 06 months, the RNI is 0.3 mcg per day , rising to 0.4 mcg per day for those aged 712 months