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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

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There is a striking and concerning lack of human evidence

10.1021/ja00172a038

Alterations in GSH homeostasis have been linked to neurodegenerative disorders, liver disease, cystic fibrosis, pulmonary and cardiovascular diseases, as well as chronic age-related diseases and the aging process itself