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It is noteworthy that the GOLD 2020 update no longer refers to ACO but instead recommends using blood eosinophil counts to guide ICS therapy in COPD

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Search Strategy A comprehensive search of PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed from database inception through the final search date

The heatmap showed a global change in upregulated and downregulated proteins from the undifferentiated state (iPSC) to the differentiated state (GF-HLCs, SM-HLCs, CTR) (Figure 3E)

Z.et al (2020)

Thus, in the study from Guerrero et al., GMD selectively induces apoptosis in OIS models