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Role of Sphingomyelinases in Cardiovascular Disease The activities of both the SMPD1 (acid sphingomyelinase) and SMPD3 (neutral sphingomyelinase) encoded genes have been shown to be associated with the development of atherosclerotic lesions

Medakas were sacrificed via overdose of anaesthesia

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Delivery of CRISPR-Cas9 into mouse zygotes by electroporation

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In the liver, IL-1-driven inflammation contributes to hepatic steatosis, fibrosis, and the progression to MASH[33,34]