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Chronic alcohol consumption leads to increased oxidative stress, and the imbalance between the production of free radicals and the antioxidant systems, such as SOD, CAT, and GPX, triggers lipid peroxidation, protein inactivation, and DNA damage leading to mitochondrial dysfunction, cell death, and increased inflammatory response

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Hugdahl, K

Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences

Inform your doctor if you are allergic to methylcobalamin or any other medications, and disclose pregnancy, breastfeeding status, medical history, and current medications to prevent adverse effects