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In current studies, the cell types that are used differ depending on the purpose of the study, and many normal primary cells, transformed cells, and tumor cell lines have been investigated

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Additionally, real-time monitoring techniques are needed to elucidate the concentration dynamics of reactive oxygen species within fibroid cells, precisely define the threshold at which their effects shift from promoting proliferation to inducing apoptosis, and simultaneously decipher the regulatory roles of E and progesterone in this equilibrium

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Figure 1 Apoptosis Apoptosis is the most prominent and widely studied mode of PCD during development (35), the process relies on the activation of a family of cysteine proteases to form an irreversible apoptotic pathway that is morphologically characterized by cell shrinkage or fragmentation, chromosome condensation, plasma membrane vesiculation, and DNA fragmentation (36, 37)

For example, DLL1 promotes differentiation of M1-TAMs while DLL1-Notch 4 facilitates T nave polarization into Th1 and Th2 (160, 161)