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The activation of the sympathetic nervous system (SNS) may be another mechanism for the inflammatory link between sleep loss and atherosclerotic CV disease, because such activation increases the bone marrow release of progenitor cells, the production of innate immune cells (monocytes), and the levels of inflammatory cytokines, and triggers endothelial dysfunction, thereby leading to systemic and vascular inflammation and atherosclerosis 206,207

Raza et al., 2021)

As people age, the prevalence of restrictive lung disease rises dramatically, from 2.7 cases per 100,000 in those between the ages of 35 and 44 to over 175 cases per 100,000 in those over 75 (Alharbi et al