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Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosis

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Elevated ferrous iron induced by ph-IOP led to a marked accumulation of pro-ferroptotic factors (lipid peroxidation and acyl CoA synthetase long-chain family member 4) and a depletion of anti-ferroptotic factors (glutathione, glutathione peroxidase 4, and nicotinamide adenine dinucleotide phosphate)

Furthermore, with developments in nanoscopic drug delivery vectors, it may be possible to use dual loaded (PTL+SSZ) nanovectors to overcome selective patient resistance towards one drug and the chemoprotective effects of the leukemia microenvironment in vivo