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The unique ability of PROMs to predict future disability progression has been previously shown, and, in some cases, these measures outperform the predictive ability of an objective neurological examination
10.1097/01.brs.0000219945.70675.dd

Methylcobalamin is a cofactor of 2 enzymes present in mammalian cells: methionine synthase and methylmalonyl-CoA mutase enzyme

European Urology

PMID: 12061743

Third, distension allows for disease "staging" by determining anatomic as opposed to functional bladder capacity and identifying the subset of patients who suffer reduced capacity as a result of fibrosis
