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Solubility and bioavailability enhancement of oridonin: a review

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doi: 10.4103/picr.PICR_55_18

ROS promotes receptor interacting serine/threonine kinase 3 (RIP3) phosphorylation, which subsequently triggers downstream mixed lineage kinase domain-like pseudokinase (MLKL) phosphorylation and activates MLKL translocation to the plasma membrane, increasing membrane permeability and inducing necrotic death in HCC tumor cells [125]