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Histopathological evaluation used a modified Mankin scoring system

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The increased NAD+ levels activate SIRT1, a protein that plays a crucial role in regulating insulin sensitivity and glucose metabolism

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The arterial endothelial cells uniquely expressed Alpl and Hey1 , the capillary endothelial cells strongly expressed Lpl , and the venous endothelial cells expressed Vwf , Hif1a , Icam1 , Lrg1 and Aplnr (Extended Data Fig