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138 Trans -interaction involves the head-to-head binding of claudins between adjacent cells, while cis -interaction involves the lateral interaction between claudins within a single membrane

We can see the intimate relationship growth hormone signals and longevity

Neurosci Lett 148(12):121125

Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth

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Meanwhile, peptides like LL37 work on breaking down stubborn biofilms (think of them as protective shields some bacteria use to hide), allowing treatments to penetrate and do their job
