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Notes 10 (1), 77
HD: Methodology, Writingoriginal draft

Potent inhibition of Acid ceramidase by novel B-13 analogues

We expressed and purified ABHD11-Flag in HEK293T cells and confirmed its hydrolase activity using a generic esterase substrate, p-nitrophenol acetate (Fig

Body contact Cutaneous exposure to aquatic cyanotoxins can occur during water-based recreational activities such as bathing and swimming

Even after drug withdrawal, treatment-induced chromatin landscape alterations (e.g., reduced H3K27me3 at key gene promoters) may persist, enabling cells to more rapidly initiate resistance mechanisms upon re-exposure to the same treatment [162, 163]
