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In these trials, which had a median treatment duration of 12 weeks, the estimated incidence rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one case of suicidal thinking or behavior for every 530 patients treated

doi: 10.1016/j.bjps.2006.04.017

At only 2% of bodyweight, the brain is relatively small, yet it consumes more than 20% of the bodys total energy