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Metabolic endotoxemia, arising from the loss of barrier integrity, is thought to be a major factor that contributes to insulin resistance and obesity 105,106,107

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These effects are mechanistically linked to dysregulation of neurodevelopmental signaling pathways, and significant downregulation of neuronal markers of neuronal differentiation and maturation, including TUJ1, MAP2, and PAX6

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Mol Biol Evol 16:826838