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Strikingly, simply increasing mitochondrial GSH levels by expressing mito-GSHf in SLC25A39/40 double knockout cells completely restored the reduced levels of mitochondrial translation machinery proteins, iron-sulfur containing proteins, and aconitase activity (Fig 4f,g)

Nutr Neurosci 27(6):637666 Emudainohwo JOT, Ben-Azu B, Adebayo OG, Aduema W, Uruaka C, Ajayi AM, Okpakpor EE, Ozolua RI (2023) Normalization of HPA Axis, Cholinergic Neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of rutin against psychosocial defeat stress

Nevertheless, it is accepted by the scientific community that more clinical studies should be undertaken in large samples of diseased populations so that the assessment of their therapeutic potential provide us with strong evidence for their efficacy and safety in clinical use

O-GlcNAcylation of high mobility group box 1 (HMGB1) alters its DNA binding and DNA damage processing activities

Similarly, the putative detection of ganoderic acid H, a triterpenoid-type compound documented for antimicrobial and antioxidant properties, may also partly underlie the disease suppression observed with DOGROF-3 (Li et al., 2012)

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