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doi: 10.1093/bioinformatics/btu393 23 WuTHuEXuSChenMGuoPDaiZet al
Hanaford and Johnson [199] review preclinical and clinical evidence for the immune system's role in the pathogenesis of mitochondrial dysfunction and disease

GO standard treatment is based on corticosteroids and radiotherapy (RT) to reduce the activity and duration of the disease

A mechanistic study revealed that SF (56.4 or 282 mol/kg/day for 6 days/week for 8 weeks) cleared A and tau accumulation by increasing levels of a heat shock protein (HSP70) and co-chaperone (CHIP), and mitigated memory deficits in a triple transgenic mouse model of AD (66)

These metabolic differences were not mirrored by changes in surface phenotypic markers for T cell subset and differentiation state (Supplementary Fig

ROS can lead to the oxidation of amino acid residues, cleavage of peptide bonds, and aggregation of proteins (Milkovic et al., 2019)
