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An increased ROS load with unaugmented Gpx/GR ratio was also modelled to demonstrate the behaviour of a system that did not have higher Gpx concentration compared with GR, as would occur without introduction of our plasmid containing the enzymes in series

Mammals have an equivalent enzyme designated as glutathione reductase (GR), which exerts a similar catalytic function than TR (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 189.Horton T.M., Petros J.A., Heddi A., Shoffner J., Kaufman A.E., Graham S.D., Jr., Gramlich T., Wallace D.C