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14 BhujabalZ.BirgisdottirA

Genes of interest for all experiments were normalized to mouse Tbp (TATA-box binding protein) mRNA expression, and the fold change in gene expression was calculated using the efficiencyCt method [40]

The samples and NRS were placed in a water bath at 37C for 5 minutes

A: ME 12 500MCG INJECTION should be used with caution in children and adolescents (aged 6 months to 18 years)

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It significantly lowers blood uric acid levels and downregulates the expression of NLRP3 and IL-1 , but these anti-inflammatory effects may be secondary consequences of reduced uric acid load, rather than their primary therapeutic target (142)