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Oxidative Medicine and Cellular Longevity 2012:324832. [doi.org]

Given that FOXO4-DRI remains in the preclinical arena (i.e., animal models, in-vitro cell culture), lets review key studies and what they suggest

Preclinical studies showed preferential reduction of abdominal and visceral adipose tissue, suggesting favorable body composition changes even when total weight loss is moderate

Ensuring adequate protein intake, maintaining hydration, and preserving sleep quality help manage fatigue

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Some individuals may have difficulty absorbing B12 from dietary sources, making injections necessary
