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Mangiferin alleviates trimethylamine-N-oxide (TMAO)-Induced atherogenesis and modulates gut microbiota in mice

Statistically, in healthy individuals, about 12 h after ED ingestion, there is an increase in systolic blood pressure by 610 mmHg, diastolic blood pressure by 36 mmHg, heart rate by about 37 beats/minute, and QT interval prolongation up to 2225 ms

While the relationship between serum TMAO and adverse cardiovascular events was established in the general population, TMAO metabolism in CKD has not been completely clarified

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Acetyl-L-carnitine (ALCAR) is a form of L-carnitine that is more easily absorbed by the brain and may have additional benefits for nerve function