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The results demonstrated that TSA concentration-dependently enhanced IKs current amplitude (EC50=64.5 M), accelerated channel activation kinetics, slowed inactivation and shifted the voltage dependence of IKs activation toward hyperpolarization (134)

doi: 10.1016/j.nutres.2018.07.005

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The authors also validated that GSH content and GPX4 activity were significantly decreased when H22 cells were co-incubated with Mn-MOF (Figures 5H, I)