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522 The contributions of the other UPR arms to lipid homeostasis have also been described, including protective effects of both the PERK/eIF2 and ATF6 branches against hepatosteatosis in ER-stressed mice and an ATF6-mediated upregulation of fatty acid oxidation and downregulation of lipogenesis in hepatocytes

Age-related reduction of mitochondrial function is accompanied by a decline in the mitochondrial capacity for ATP production by oxidative phosphorylation [62], a reduction in the NAD + pool [63] by consuming processes (PARP, CD38, and SIRT1) [64], and further an increase in ROS generation by an inefficient electron transport chain (ETC) [26]

The siderophore yersiniabactin binds copper to protect pathogens during infection
HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer)

There are several genetic strains of HBV (genotypes A-H), which vary in geographic distribution, response to treatment, and risk of progression to advanced liver disease (Liaw 2009
