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doi: 10.1100/tsw.2010.104

sc) did not improve renal outcomes in patients with acute renal failure, compared to placebo, after a mean period of 10 days.36 To account for co-founding factors in acute renal injury, recombinant IGF-1 administration was also tested in transplant patients receiving a cadaveric kidney allograft.37 In these patients, treatment with IGF-1 similarly failed to significantly improve renal function compared to placebo, suggesting that the regenerative effects of IGF-1 observed in animal models of renal ischemia may not be directly scalable to patients with acute renal failure