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Tight junction structures are made up of various elements, including transmembrane proteins (claudins, occludin, and tricellulin), tight junction-associated proteins (junctional adhesion molecules 13), and intracellular scaffold proteins (zonula occludens 13), and regulate paracellular passage of molecules based on charge and size selectivity under homeostatic conditions (10)

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For instance, the total NADP(H) is about 420 nmol/g wet weight in rat liver and 59% of total NADP(H) is found in mitochondria, and 30 nmol/g wet weight in skeletal muscle, 5,8 and the NADPH concentration in the cytosol is 3.1 0.3 and 37 2 M in the mitochondrial matrix in HeLa cells

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its ability to modulate ROS may also limit apoptosis and cell death in cancer cells to promote rampant cell growth and resistance to chemotherapy [see [132] for review]