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2.4 Effects of metabolism on immune cells in the TME Tumor-infiltrating immune cells have dual characteristics, some of which have the function of inhibiting tumor proliferation and metastasis, such as CD8+ cytotoxic T cells, natural killer (NK) cells, M1 macrophages, dendritic cells (DCs), etc., while others may be beneficial to tumor development, including Treg cells, M2 macrophages (78)

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Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis highlights tentative relevance of diabetes-related traits