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2 Among these, cold exposure and fasting are well-studied paradigms that necessitate metabolic flexibility, prioritizing fatty acid oxidation over glucose catabolism to sustain systemic energy balance while sparing glucose for obligate tissues such as the brain

Declarations Conflict of interest DM, CdA, FG, MM, GG, MP, MC, NV, CP, CS, RSA and AC have no conflicts of interest to declare that are relevant to the content of this article

Histopathologically, both types may be junctional, compound or intradermal (intra mucosal), but CMN generally shows a diffuse band-like infiltrate of melanocytes streaming through collagen bundles rather than the classic cell nest formation of acquired nevus [1, 5]

JAMA Dermatol 156:570575 Wu CS, Cioanca AV, Gelmi MC, Wen L, Di Girolamo N, Zhu L, Natoli R, Conway RM, Petsoglou C, Jager MJ, Mccluskey PJ, Madigan MC (2023) The multifunctional human ocular melanocortin system

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