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This environment not only results in structural changes but also influences cell behavior through biomechanical signals and interactions with cell surface receptors ( 3.5 Immune system involvement 3.5.1 Innate immune cells in radiation skin fibrosis In radiation-induced skin fibrosis, the innate immune system, particularly macrophages, have a critical effect on both initiating and perpetuating the fibrotic process

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Updated on April 30th, 2026 Clinical trials progress through four phases, with Phase I testing safety in 20-100 participants and Phase III comparing new treatments to standard care in hundreds to thousands of patients