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10.1038/s41586-020-2623-z 216 UetaT.InoueT.FurukawaT.TamakiY.NakagawaY.ImaiH.et al (2012)
Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate

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This mechanical stress can cause the peptide to denature (unfold), which destroys its biological activity

Ma N, Xu E, Luo Q, Song G

Methods Enzymol 268:237246 Guibourt NJBG (1820) Abridged History of Simple Drugs Colas 2:160161 Guillen-Sans R, Guzman-Chozas M (1998) The thiobarbituric acid (TBA) reaction in foods: a review
