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Hydroxysteroid 17-dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

Extracellular free VLCFAs (C24:0 and C26:0) induced tumor necrosis factor and glutamate secretion and depleted the total GSH in cALD

In turn, the ability to upregulate glutathione synthesis in response to demands is hypothesised to be an important determinant of cell survival (Reference Maher11)

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5.3 Drug application The routine therapeutic drugs for osteoporosis include BPs, selective estrogen receptor modulators, and parathyroid hormone analogs, matched to the intervention of osteoporosis under different etiologies, fulfilling ideal efficacy while accompanied by certain adverse effects (33)