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11, eadp7171

The identified residues in the native enzyme ( p1 ) were replaced with Cys residues to obtain variants for mono-crosslinking ( p2 : Thr3Cys, p3 : Gln174Cys) and for bis-crosslinking ( p4 : Thr3Cys and Gln174Cys)

Repeated overdoses can also occur with self-harm intent (often termed staggered overdoses), and similarly carry an increased risk of hepatotoxicity when compared to acute self-harm overdoses *

OTUB1: OTU domain-containing ubiquitin aldehyde-binding protein 1

Intranasal drug delivery: a non-invasive approach for the better delivery of neurotherapeutics