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In extreme cases of excessive glutamate receptor activity, direct lethal damage to the neurons (i.e., excitotoxicity) can occur, in which the neurons literally are excited to death

Canagliflozin (Cana), an anti-diabetes drug, also promotes the system Xc-/GPX4 axis to inhibit ferroptosis, attenuating cardiovascular diseases (Du et al

6c) than in the control group

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In the early stages of neurodegenerative diseases, when the autophagic function of neurons is not yet fully impaired, quinone-anthracene derivatives are more effective in restoring autophagic flux, playing a positive role in disease treatment