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Trial registration The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials ( www.irct.ir ) on 28/08/2021 (registration number: IRCT20200920048782N1).

The Precision Peptide Genetic Test analyzes GSTM1 and GSTT1 the glutathione S-transferase genes whose null deletions eliminate the tertiary Phase 2 backstop against reactive estrogen quinones

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