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Common sample pretreatment techniques like derivatization and SPE are discussed for their efficacy in improving detection sensitivity and selectivity

However, their clinical use is restricted by safety concerns and suboptimal pharmacokinetics

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3 (download ZIP Full set of unprocessed thrombosis images

J Gastroenterol Hepatol 2000;15:706-717

Their accumulation in adipose tissue leads to insulin resistance and inflammation, both of which contribute to the development of atherosclerosis as insulin resistance progresses, the adipose tissue secretes higher levels of adipokines, signaling molecules that promote inflammation and increase the risk of atherosclerosis