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Batool, A

The inhibitors, dissolved in dimethyl sulfoxide (DMSO), were used in the following concentrations: STAT3 inhibitor AG-490 (50uM/L) (Selleck Chemicals, Houston, USA), IGF-1R inhibitor AG-1024 (5uM/L) (Selleck Chemicals), AKT inhibitor MK-2206 2HCl (5uM/L) (Selleck Chemicals, Houston, USA), JAK1 inhibitor ZM 39923 HCl (50uM /L) (Selleck Chemicals, Houston, USA)

It might be interesting to use such compounds in clinical practice as a supplement, especially as an add-on to symptom-dependent drug therapy, albeit with due caution

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Given these limitations, we explored whether small molecules expressed by iPS cell-derived retinal tissue could provide neurovasculotrophic rescue in models of retinal degeneration

Zechmann et al