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An initial injury often cascades into compensatory patterns that stress surrounding structures

[DOI] [PubMed] [Google Scholar] Bloedon LT, Jeffcoat AR, Lopaczynski W, Schell MJ, Black TM, Dix KJ, Thomas BF, Albright C, Busby MG, Crowell JA, and Zeisel SH (2002) Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women

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Although the underlying mechanisms were different between SOD1 and C9orf72 models, treatment of cultured astrocytes with IL10/CCL2nAb was effective (Chevalier et al., 2024)