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Therefore, Met utilization may alter the DNA and histones methylation level, influencing the overall abundance of mRNA and proteins, and, consequently, the upcoming phenotype

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Shin MK, Kim MK, Bae YS, Jo I, Lee SJ, Chung CP, et al
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Although resembling glucose deprivation (pull mechanism), troglitazone further increases the NH 4 + production (additive push+pull mechanism) exceeding the fall in alanine production (pull mechanism alone)

In addition, compelling evidence suggests that DNA damage response (DDR) signaling is a predominant mechanism associated with the build-up of DNA damage, aging, and cell senescence (Malaquin et al., 2015)
