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A randomized, placebo-controlled, double-blind clinical trial with parallel design was conducted on 73 healthy overweight or obese women

Association between -klotho and deep white matter lesions in the brain: a pilot case control study using brain MRI

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[140] found that puerarin elevated the level of autophagy in STZ-induced DN mice, particularly under conditions of endoplasmic reticulum stress (ERS), through the activation of the RNA-dependent protein kinase-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 subunit (eIF2)/ATF4 signaling pathway

Compound 31 , the cis isomer of 30 , demonstrated a lower affinity to the enzyme (Ki = 30.4 nM)